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Literature summary for 3.4.21.4 extracted from

  • Stenman, M.; Ainola, M.; Valmu, L.; Bjartell, A.; Ma, G.; Stenman, U.H.; Sorsa, T.; Luukkainen, R.; Konttinen, Y.T.
    Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue (2005), Am. J. Pathol., 167, 1119-1124.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.4

Application

Application Comment Organism
medicine use of enzyme and its regulators as markers of prognosis and disease activity in rheumatoid arthritis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
tumor-associated trypsin inhibitor specific inhibition of degradation of gelatin and collagen type II Bos taurus
tumor-associated trypsin inhibitor specific inhibition of degradation of gelatin and collagen type II Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Gelatin + H2O Homo sapiens
-
 ?
-
 ?
human cartilage collagen type II + H2O Homo sapiens use of enzyme and its regulators as markers of prognosis and disease activity in rheumatoid arthritis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
 isoform trypsin-2
-

Source Tissue

Source Tissue Comment Organism Textmining
stromal cell of rheumatoid arthritis synovial membrane Homo sapiens
-
synovial tissue fibroblast-like synovial lining of rheumatoid arthritis synovial membrane Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
human cartilage collagen type II + H2O
-
 Homo sapiens ?
-
 ?
human cartilage collagen type II + H2O use of enzyme and its regulators as markers of prognosis and disease activity in rheumatoid arthritis Homo sapiens ?
-
 ?
additional information no substrate: type II collagen Bos taurus ?
-
 ?