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Literature summary for 3.4.21.39 extracted from
- Mast cell chymase in keloid induces profibrotic response via transforming growth factor-beta1/Smad activation in keloid fibroblasts (2014), Int. J. Clin. Exp. Pathol., 7, 3596-3607.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keloid | - |
Homo sapiens | - |
| mast cell | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mast cell chymase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | gene expression and activity of mast cell chymase in keloid are significantly higher than those in normal skin | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mast cell chymase plays an important role in keloid formation through transforming growth factor-beta1/Smad signaling pathway. Mast cell chymase upregulates Smad proteins in keloid fibroblasts | Homo sapiens |
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Release 2023.1 (January 2023)
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