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Literature summary for 3.4.21.39 extracted from

  • Takai, S.; Jin, D.; Ohzu, M.; Tanaka, K.; Miyazaki, M.
    Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes (2009), J. Pharmacol. Sci., 110, 459-465.
    View publication on PubMed
Search for more literature for 3.4.21.39

Inhibitors

Inhibitors Comment Organism Structure
TY-51469 i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid, TY-51469 has a high specificity for chymase Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Mesocricetus auratus
-
 angiotensin II + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Mesocricetus auratus angiotensin II + ?
-
 ?
succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O
-
 Mesocricetus auratus succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin
-
 ?

General Information

General Information Comment Organism
malfunction chymase inhibition protects against pancreatic islet disorganization Mesocricetus auratus