Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SUN C8257 | - |
Homo sapiens | |
SUN13350 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | chymase can activate eosinophils to markedly induce the release of chemokines CCL2 (monocyte chemotactic protein-1), CXCL1 (growth-regulated oncogene-alpha), CXCL8 (IL-8), and inflammatory cytokine IL-6, chymase activates ERK, p38 mitogen-activated protein kinase, Janus-activated kinase, Akt and nuclear factor-kappaB in eosinophils by induction of phosphorylation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mast cell | skin mast cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | chymase can activate eosinophils to markedly induce the release of chemokines CCL2 (monocyte chemotactic protein-1), CXCL1 (growth-regulated oncogene-alpha), CXCL8 (IL-8), and inflammatory cytokine IL-6, chymase activates ERK, p38 mitogen-activated protein kinase, Janus-activated kinase, Akt and nuclear factor-kappaB in eosinophils by induction of phosphorylation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mast-cell-derived chymase | - |
Homo sapiens |