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Literature summary for 3.4.21.39 extracted from

  • Wong, C.K.; Ng, S.S.; Lun, S.W.; Cao, J.; Lam, C.W.
    Signalling mechanisms regulating the activation of human eosinophils by mast-cell-derived chymase: implications for mast cell-eosinophil interaction in allergic inflammation (2009), Immunology, 126, 579-587.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SUN C8257
-
 Homo sapiens
SUN13350
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens chymase can activate eosinophils to markedly induce the release of chemokines CCL2 (monocyte chemotactic protein-1), CXCL1 (growth-regulated oncogene-alpha), CXCL8 (IL-8), and inflammatory cytokine IL-6, chymase activates ERK, p38 mitogen-activated protein kinase, Janus-activated kinase, Akt and nuclear factor-kappaB in eosinophils by induction of phosphorylation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell skin mast cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information chymase can activate eosinophils to markedly induce the release of chemokines CCL2 (monocyte chemotactic protein-1), CXCL1 (growth-regulated oncogene-alpha), CXCL8 (IL-8), and inflammatory cytokine IL-6, chymase activates ERK, p38 mitogen-activated protein kinase, Janus-activated kinase, Akt and nuclear factor-kappaB in eosinophils by induction of phosphorylation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
mast-cell-derived chymase
-
 Homo sapiens