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Literature summary for 3.4.21.39 extracted from

  • Maruoka, H.; Muto, T.; Tanaka, T.; Imajo, S.; Tomimori, Y.; Fukuda, Y.; Nakatsuka, T.
    Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 3435-3439.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
Homo sapiens
2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
Homo sapiens
2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
Homo sapiens
3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
Homo sapiens
3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
Homo sapiens
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
-
Homo sapiens
4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
-
Homo sapiens
5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
-
Homo sapiens
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
-
Homo sapiens
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylethyl)-1,4-diazepane-1-carboxamide
-
Homo sapiens
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylpropyl)-1,4-diazepane-1-carboxamide
-
Homo sapiens
6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(2-phenylethyl)-1,4-diazepane-1-carboxamide
-
Homo sapiens
6-(5-chloro-2-methoxybenzyl)-N-(2-methyl-1-phenylpropyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
Homo sapiens
6-(5-chloro-2-methoxybenzyl)-N-(diphenylmethyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
Homo sapiens
methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
-
Homo sapiens
N-benzyl-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
-
Homo sapiens
N-benzyl-6-(5-chloro-2-methoxybenzyl)-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
-
Homo sapiens 2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00024
-
-
Homo sapiens 3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0003
-
-
Homo sapiens 2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00034
-
-
Homo sapiens 2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00041
-
-
Homo sapiens 2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00046
-
-
Homo sapiens 4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
0.00047
-
-
Homo sapiens 4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0005
-
-
Homo sapiens 2-amino-4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00054
-
-
Homo sapiens 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.00063
-
-
Homo sapiens 4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0018
-
-
Homo sapiens 4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
0.0025
-
-
Homo sapiens 2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0026
-
-
Homo sapiens methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
0.0028
-
-
Homo sapiens 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylpropyl)-1,4-diazepane-1-carboxamide
0.003
-
-
Homo sapiens 6-(5-chloro-2-methoxybenzyl)-N-(2-methyl-1-phenylpropyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
0.0041
-
-
Homo sapiens 5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]-2-hydroxybenzoic acid
0.0043
-
-
Homo sapiens 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0049
-
-
Homo sapiens N-benzyl-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
0.005
-
-
Homo sapiens 4-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0053
-
-
Homo sapiens 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylethyl)-1,4-diazepane-1-carboxamide
0.0061
-
-
Homo sapiens 2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.01
-
IC50 above 0.01 mM Homo sapiens 2-amino-4-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.01
-
IC50 above 0.01 mM Homo sapiens 3-[(1R)-1-([[(6S)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0142
-
-
Homo sapiens 2-amino-5-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoic acid
0.0445
-
-
Homo sapiens 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(2-phenylethyl)-1,4-diazepane-1-carboxamide
0.0514
-
-
Homo sapiens methyl 3-[(1R)-1-([[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl]amino)propyl]benzoate
0.0693
-
-
Homo sapiens 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
0.1
-
IC50 above 0.1 mM Homo sapiens 6-(5-chloro-2-methoxybenzyl)-N-(diphenylmethyl)-3,7-dioxo-1,4-diazepane-1-carboxamide
0.1
-
IC50 above 0.1 mM Homo sapiens N-benzyl-6-(5-chloro-2-methoxybenzyl)-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide