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Literature summary for 3.4.21.39 extracted from

  • Tani, M.; Gyobu, Y.; Sasaki, T.; Takenouchi, O.; Kawamura, T.; Kamimura, T.; Harada, T.
    SF2809 compounds, novel chymase inhibitors from Dactylosporangium sp. 1. Taxonomy, fermentation, isolation and biological properties (2004), J. Antibiot., 57, 83-88.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
SF2809-I the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0073 mM Homo sapiens
SF2809-II the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000041 mM Homo sapiens
SF2809-III the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0021 mM Homo sapiens
SF2809-IV the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000081 Homo sapiens
SF2809-V the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000043 mM Homo sapiens
SF2809-VI the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000014 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Ala-His-Pro-Phe-4-nitroanilide + H2O
-
Homo sapiens N-succinyl-Ala-His-Pro-Phe + 4-nitroaniline
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000014
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000014 mM Homo sapiens SF2809-VI
0.000041
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000041 mM Homo sapiens SF2809-II
0.000043
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000043 mM Homo sapiens SF2809-V
0.000081
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.000081mM Homo sapiens SF2809-IV
0.0021
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0021 mM Homo sapiens SF2809-III
0.0073
-
the inhibitor is isolated from the fermentation broth of Dactylosporangium sp., specific chymase inhibitor with little or no inhibitory activity against chymotrypsin or cathepsin G, IC50: 0.0073 mM Homo sapiens SF2809-I