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Literature summary for 3.4.21.38 extracted from

  • Davie, E.W.; Fujikawa, K.; Kurachi, K.; Kisiel, W.
    The role of serine proteases in the blood coagulation cascade (1979), Adv. Enzymol. Relat. Areas Mol. Biol., 48, 277-318.
    View publication on PubMed
Search for more literature for 3.4.21.38

Inhibitors

Inhibitors Comment Organism Structure
antithrombin III inhibition is accelerated 300fold to 500fold by the addition of heparin, heparin alone has no effect Bos taurus
C1 esterase inhibitor
-
 Bos taurus
diisopropyl phosphofluoridate
-
 Bos taurus
Lima bean trypsin inhibitor
-
 Bos taurus
phenyl methylsulfonyl fluoride
-
 Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid sequence of the heavy chain, the active site region contains Asp-Ala-Cys-Gln-Gly-Asp-Ser-Gly-Gly sequence Bos taurus
28000
-
 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds Bos taurus
46000
-
 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor VII + H2O Bos taurus enzyme is involved in the blood coagulation cascade ?
-
 ?
factor XI + H2O Bos taurus enzyme is involved in the blood coagulation cascade ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the conversion of factor XII to factor XIIa is due to the cleavage of a specific internal Arg-Val peptide bond Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl arginine ethyl ester + H2O
-
 Bos taurus benzoyl-Arg + ethanol
-
 ?
factor VII + H2O enzyme is involved in the blood coagulation cascade Bos taurus ?
-
 ?
factor VII + H2O
-
 Bos taurus factor VIIa
-
 ?
factor XI + H2O
-
 Bos taurus factor XIa + ?
-
 ?
factor XI + H2O enzyme is involved in the blood coagulation cascade Bos taurus ?
-
 ?
N-benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O
-
 Bos taurus ?
-
 ?
plasminogen proactivator + H2O
-
 Bos taurus ?
-
 ?
prekallikrein + H2O
-
 Bos taurus ?
-
 ?
tosyl arginine methyl ester + H2O
-
 Bos taurus tosyl-Arg + methanol
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 28000 + 1 * 46000, heavy chain and light chain held together by disulfide bonds Bos taurus