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Literature summary for 3.4.21.37 extracted from
- Prevention of leukocyte activation by the neutrophil elastase inhibitor, sivelestat, in the hepatic microcirculation after ischemia-reperfusion (2009), J. Surg. Res., 155, 311-317.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | neutrophil elastase inhibitor sivelestat improves liver injury and prevents the increase of tissue malondialdehyde, MDA. Liver ischemia-reperfusion injury is one of the most serious complications of hepatic surgery | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sivelestat | a neutrophil elastase inhibitor, effect on leukocyte dynamics in the liver microcirculation after hepatic ischemia-reperfusion, Leukocyte dynamics in sinusoids, overview. The inhibitor significantly decreases the number of adherent leukocytes and prevents perfusion disturbance, overview | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| neutrophil | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| neutrophil elastase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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