Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | intracellular sorting/trafficking of neutrophil elastase in cyclic hematopoiesis dogs, neutrophils from cyclic hematopoiesis dogs accumulate large amounts of higher molecular weight elastase precursors compared to normal dogs, overview | Canis lupus familiaris | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | neutrophile elastase is produced as a precursor protein and subjected to extensive modification and processing before it is stored as an active protease in neutrophil primary granules | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | the mature, processed neutrophile elastase is a major component of neutrophil primary granules | Canis lupus familiaris | - |
Synonyms | Comment | Organism |
---|---|---|
neutrophil elastase | - |
Canis lupus familiaris |
General Information | Comment | Organism |
---|---|---|
malfunction | canine cyclic hematopoiesis, caused by a mutation of AP3B1 encoding the b3A subunit of adaptor protein complex L3, AP-3, and a model of human cyclic neutropenia and severe congenital neutropenia, is characterized by a periodic reduced neutrophil count and decreased neutrophil elastase enzymatic activity. Intracellular sorting/trafficking of neutrophil elastase in cyclic hematopoiesis dogs, neutrophils from cyclic hematopoiesis dogs accumulate large amounts of higher molecular weight elastase precursors compared to normal dogs, overview | Canis lupus familiaris |