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BRENDA support

Literature summary for 3.4.21.37 extracted from

  • Meng, R.; Bridgman, R.; Toivio-Kinnucan, M.; Niemeyer, G.P.; Vernau, W.; Hock, T.; Lothrop, C.D.
    Neutrophil elastase-processing defect in cyclic hematopoietic dogs (2010), Exp. Hematol., 38, 104-115.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information intracellular sorting/trafficking of neutrophil elastase in cyclic hematopoiesis dogs, neutrophils from cyclic hematopoiesis dogs accumulate large amounts of higher molecular weight elastase precursors compared to normal dogs, overview Canis lupus familiaris
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Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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Posttranslational Modification

Posttranslational Modification Comment Organism
additional information neutrophile elastase is produced as a precursor protein and subjected to extensive modification and processing before it is stored as an active protease in neutrophil primary granules Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil the mature, processed neutrophile elastase is a major component of neutrophil primary granules Canis lupus familiaris
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Synonyms

Synonyms Comment Organism
neutrophil elastase
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Canis lupus familiaris

General Information

General Information Comment Organism
malfunction canine cyclic hematopoiesis, caused by a mutation of AP3B1 encoding the b3A subunit of adaptor protein complex L3, AP-3, and a model of human cyclic neutropenia and severe congenital neutropenia, is characterized by a periodic reduced neutrophil count and decreased neutrophil elastase enzymatic activity. Intracellular sorting/trafficking of neutrophil elastase in cyclic hematopoiesis dogs, neutrophils from cyclic hematopoiesis dogs accumulate large amounts of higher molecular weight elastase precursors compared to normal dogs, overview Canis lupus familiaris