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Literature summary for 3.4.21.37 extracted from

  • Zhang, M.; Liu, N.; Park, S.M.; Wang, Y.; Byrne, S.; Murmann, A.E.; Bahr, S.; Peter, M.E.; Olson, S.T.; Belaaouaj, A.; Ashton-Rickardt, P.G.
    Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa (2007), J. Immunol., 179, 4390-4396.
    View publication on PubMed
Search for more literature for 3.4.21.37

Inhibitors

Inhibitors Comment Organism Structure
serine protease inhibitor 6 weak inhibition in vivo Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
azurophil granule
-
 Mus musculus 42582
-

Metals/Ions

Metals/Ions Comment Organism Structure
Na+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme digests microbes after phagocytosis in polymorphonuclear neutrophils, as well as extracellularly, but causes tissue damage and inflammation in the latter case, serine protease inhibitor 6-deficient Spi6 KO mice have increased neutrophil immunity to Pseudomonas aeruginosa, enzyme inhibitor Spi6 protects the cells from self-inflicted damage, the enzyme protects against Pseudomonas aeruginosa infection, overview ?
-
 ?
additional information Mus musculus C57BL/6 the enzyme digests microbes after phagocytosis in polymorphonuclear neutrophils, as well as extracellularly, but causes tissue damage and inflammation in the latter case, serine protease inhibitor 6-deficient Spi6 KO mice have increased neutrophil immunity to Pseudomonas aeruginosa, enzyme inhibitor Spi6 protects the cells from self-inflicted damage, the enzyme protects against Pseudomonas aeruginosa infection, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
polymorphonuclear neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme digests microbes after phagocytosis in polymorphonuclear neutrophils, as well as extracellularly, but causes tissue damage and inflammation in the latter case, serine protease inhibitor 6-deficient Spi6 KO mice have increased neutrophil immunity to Pseudomonas aeruginosa, enzyme inhibitor Spi6 protects the cells from self-inflicted damage, the enzyme protects against Pseudomonas aeruginosa infection, overview Mus musculus ?
-
 ?
additional information the enzyme digests microbes after phagocytosis in polymorphonuclear neutrophils, as well as extracellularly, but causes tissue damage and inflammation in the latter case, serine protease inhibitor 6-deficient Spi6 KO mice have increased neutrophil immunity to Pseudomonas aeruginosa, enzyme inhibitor Spi6 protects the cells from self-inflicted damage, the enzyme protects against Pseudomonas aeruginosa infection, overview Mus musculus C57BL/6 ?
-
 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Mus musculus N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?
N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Mus musculus C57BL/6 N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
HNE
-
 Mus musculus
neutrophil elastase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Mus musculus