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Literature summary for 3.4.21.37 extracted from

  • Honore, S.; Attalah, H.L.; Azoulay, E.; Soussy, C.J.; Saudubray, F.; Harf, A.; Brochard, L.; Delclaux, C.
    Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries (2004), Shock, 22, 131-136.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
EPI-hNE-4 highly specific, potent inhibitor, protective effect in repeated injury animal model Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Rattus norvegicus involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, could participate in neutrophil migration ? protein cleaved at at least one location ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Sprague-Dawley rats, repeated lung injury model
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Rattus norvegicus acetyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?
Elastin + H2O
-
 Rattus norvegicus ?
-
 ?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged, could participate in neutrophil migration Rattus norvegicus ? protein cleaved at at least one location ?