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Literature summary for 3.4.21.36 extracted from
- Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase (2006), J. Biol. Chem., 281, 3452-3457.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging-drop vapour diffusion method. X-ray structure of a covalent serpin-proteinase complex, alpha1-proteinase inhibitor with pancreatic elastase | Sus scrofa |
| in complex with alpha1-proteinase inhibitor, hanging drop vapour diffusion method with 0.2 M bicine buffer, pH 8.1, 60 mM sodium citrate, and 16-18% polyethyleneglycol 3350 | Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha1-proteinase inhibitor | - |
Sus scrofa | |
| serpin | active site distortion is sufficient for proteinase inhibition by serpins | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
| Sus scrofa | P00772 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| chromatofocusing and Superdex-75 gel filtration | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-Ala-Ala-Ala-p-nitroanilide + H2O | - |
Sus scrofa | succinyl-Ala-Ala-Ala + p-nitroaniline | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PPE | - |
Sus scrofa |
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Release 2023.1 (January 2023)
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