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Literature summary for 3.4.21.35 extracted from

  • Gao, L.; Chao, L.; Chao, J.
    A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor (2010), Exp. Cell Res., 316, 376-389.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.35

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin delays skin wound healing Rattus norvegicus
EGFR inhibitor blocks tissue kallikrein's skin wound healing effect Rattus norvegicus
icatibant blocks tissue kallikrein's skin wound healing effect Rattus norvegicus
additional information neutralizing tissue kallikrein antibody delays skin wound healing Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by affinity column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
salivary gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Val-Leu-Arg-4-nitroanilide + H2O
-
 Rattus norvegicus D-Val-Leu-Arg + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
KLK1
-
 Rattus norvegicus
tissue kallikrein
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function tissue kallikrein promotes cell migration and proliferation of HaCaT keratinocytes in a concentration- and time-dependent manner. Active TK stimulates keratinocyte migration independent of kinin, kinin B2 receptor and NO formation. Tissue kallikrein-induced keratinocyte migration is dependent on PAR1 activation and EGFR phosphorylation. Local application of tissue kallikrein promotes skin wound healing. Signaling pathways mediated by tissue kallikrein promote keratinocyte migration through activation of the PAR1-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR transactivation Rattus norvegicus