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Literature summary for 3.4.21.34 extracted from
- Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa (2002), J. Biol. Chem., 277, 47804-47809.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alzheimer's amyloid beta-protein precursor | weak inhibition | Homo sapiens | |
| additional information | no inhibition by corn trypsin inhibitor | Homo sapiens | |
| plasma kallikrein-specific Kunitz domain inhibitor | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-hepatocyte growth factor + H2O | i.e. HGF, two independent cleavage sites: Arg494-Val495, kinetically preferred, and Arg424-His425, recombinant mutant HGF R424A/R494E is no substrate | Homo sapiens | hepatocyte growth factor beta-chain + hepatocyte growth factor alpha-chain + 10 kDa fragment of the alpha-chain | activation of hepatocyte growth factor | ? |  |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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