Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.27 extracted from

  • Gailani, D.; Geng, Y.; Verhamme, I.; Sun, M.; Bajaj, S.; Messer, A.; Emsley, J.
    The mechanism underlying activation of factor IX by factor XIa (2014), Thromb. Res., 133, S48-S51.
No PubMed abstract available
Search for more literature for 3.4.21.27

Activating Compound

Activating Compound Comment Organism Structure
factor XIIa
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor IX + H2O Homo sapiens after binding to factor XIa, factor IX undergoes a single cleavage to form the intermediate factor IXalpha. FIXalpha then rebinds to the A3 domain to undergo a second cleavage, generating factor IXalphabeta factor IXa + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor IX + H2O after binding to factor XIa, factor IX undergoes a single cleavage to form the intermediate factor IXalpha. FIXalpha then rebinds to the A3 domain to undergo a second cleavage, generating factor IXalphabeta Homo sapiens factor IXa + ?
-
 ?

Subunits

Subunits Comment Organism
dimer the dimer is required for normal function in vivo Homo sapiens

Synonyms

Synonyms Comment Organism
factor XIa
-
 Homo sapiens
FXIa
-
 Homo sapiens