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Literature summary for 3.4.21.27 extracted from
- Factor XI and traveling waves: The key to understanding coagulation in hemophilia? (2013), Expert Rev. Hematol., 6, 111-113.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| factor XIIa | - |
Homo sapiens | |
| thrombin | the enzyme can be activated, albeit slowly, by thrombin | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | Homo sapiens | - |
factor IXa + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor IX + H2O | - |
Homo sapiens | factor IXa + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor XIa | - |
Homo sapiens |
| FXIa | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | factor XI deficiency can lead to delayed clot formation and decreased thrombin generation | Homo sapiens |
| physiological function | factor XI is important in the tissue factor-independent propagation phase of clot formation, not in the initiation process | Homo sapiens |
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