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Literature summary for 3.4.21.27 extracted from

  • Schumacher, W.A.; Luettgen, J.M.; Quan, M.L.; Seiffert, D.A.
    Inhibition of factor XIa as a new approach to anticoagulation (2010), Arterioscler. Thromb. Vasc. Biol., 30, 388-392.
    View publication on PubMed
Search for more literature for 3.4.21.27

Activating Compound

Activating Compound Comment Organism Structure
activated factor VII
-
 Mus musculus
activated factor VII
-
 Homo sapiens
desmopressin
-
 Homo sapiens

Application

Application Comment Organism
drug development activated factor XI inhibition as a viable method to increase the ratio of benefit to risk in an antithrombotic drug Mus musculus
drug development activated factor XI inhibition as a viable method to increase the ratio of benefit to risk in an antithrombotic drug Rattus norvegicus
drug development activated factor XI inhibition as a viable method to increase the ratio of benefit to risk in an antithrombotic drug Oryctolagus cuniculus
drug development activated factor XI inhibition as a viable method to increase the ratio of benefit to risk in an antithrombotic drug Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
heparin
-
 Mus musculus
additional information potent activated factor VII inhibition with insect-derived serine protease inhibitor, but this protein is only 10fold selective over activated factor X. Inhibition by FXI neutralizing antibodies, which allow preexisting activated factor XI to remain active Mus musculus
additional information a monoclonal antibody against FXI or activated factor XI reduces thrombus formation in balloon-injured iliac arteries Oryctolagus cuniculus
additional information ketoarginine-based peptidomimetics are irreversible inhibitors of actived factor XI and form a covalent bond to the catalytic serine of the enzyme. Intravenous infusion is efficacious in a rat model of venous thrombosis. A pyridyl analog in a rat mesenteric bleeding model at a 4fold efficacious dose does not alter bleeding time Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P03951
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
additional information hemophilia C (deficiency in FXI) is present in both sexes Homo sapiens
-

Synonyms

Synonyms Comment Organism
factor XI
-
 Mus musculus
factor XI
-
 Rattus norvegicus
factor XI
-
 Oryctolagus cuniculus
factor XI
-
 Homo sapiens
FXI
-
 Mus musculus
FXI
-
 Rattus norvegicus
FXI
-
 Oryctolagus cuniculus
FXI
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus antisense oligonucleotide produces near-complete inhibition of hepatic FXI mRNA down

General Information

General Information Comment Organism
malfunction a deficiency in FXI (hemophilia C) results in a more benign bleeding phenotype compared with a deficiency in either FVIII (hemophilia A) or FIX (hemophilia B). Most hemophilia C cases involve Ashkenazi Jews and result from either of 2 mutations in the FXI gene (E117X and F283L). Greater than 180 mutations are present but in lesser frequency. FXI deficiency also arises from acquired inhibitors that neutralize its activity, these patients may not respond well to FXI replacement therapy. Bleeding in those with hemophilia C is rarely spontaneous, it tends to occur in response to surgery or trauma, and especially in tissue prone to fibrinolysis (the urinary track or oral cavity). Prolonged activated partial thromboplastin time due to FXI deficiency Homo sapiens
malfunction FXI-null mice are healthy, and their reproduction follows the expected mendelian ratios without impaired fecundity. FXI-null mice are protected against oxidative iron chloride-induced carotid artery thrombosis and infusion of human FXI reverses this protection. Thrombus formation in FXI-null mice is also reduced in response to laser injury of arterioles in the cremaster muscle. FXI deletion is also effective in preserving carotid artery blood flow in response to compression injury Mus musculus
physiological function FXI is a biomarker with increased levels reported as a risk factor for venous thromboembolism and myocardial ischemia or stroke Homo sapiens
physiological function involvment of FXI in thrombosis, role for activated factor FXI in tissue infammation Mus musculus