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Literature summary for 3.4.21.26 extracted from

  • Savolainen, M.H.; Yan, X.; Myoehaenen, T.T.; Huttunen, H.J.
    Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction (2015), J. Biol. Chem., 290, 5117-5126.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Sus scrofa

Protein Variants

Protein Variants Comment Organism
S554A enzymatically inactive mutant Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
KYP-2047 i.e. 4-phenylbutanoyl-l-prolyl-2(S)-cyanopyrrolidine Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-synulein + H2O Sus scrofa the enzyme binds to alpha-synuclein and enhances its dimerization ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-synulein + H2O the enzyme binds to alpha-synuclein and enhances its dimerization Sus scrofa ?
-
 ?
succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
PREP
-
 Sus scrofa