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Literature summary for 3.4.21.26 extracted from

  • Kaszuba, K.; Rog, T.; Danne, R.; Canning, P.; Fueloep, V.; Juhasz, T.; Szeltner, Z.; St Pierre, J.F.; Garcia-Horsman, A.; Maennistoe, P.T.; Karttunen, M.; Hokkanen, J.; Bunker, A.
    Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase (2012), Biochimie, 94, 1398-1411.
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
 Sus scrofa
4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine
-
 Sus scrofa
benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
 Sus scrofa
cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide
-
 Sus scrofa
Z-Pro-prolinal
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P23687
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Gly-Pro-2-naphthylamide + H2O
-
 Sus scrofa Z-Gly-Pro + 2-naphthylamine
-
 ?

Synonyms

Synonyms Comment Organism
PREP
-
 Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000015
-
 4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine at 25°C between pH 5.5 and 9.5 Sus scrofa
0.00000002
-
 4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine at 25°C between pH 5.5 and 9.5 Sus scrofa
0.000000055
-
 benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine at 25°C between pH 5.5 and 9.5 Sus scrofa
0.00000015
-
 cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide at 25°C between pH 5.5 and 9.5 Sus scrofa
0.0000002
-
 Z-Pro-prolinal at 25°C between pH 5.5 and 9.5 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000002
-
 at 25°C between pH 5.5 and 9.5 Sus scrofa 4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine
0.00000026
-
 at 25°C between pH 5.5 and 9.5 Sus scrofa 4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
0.0000003
-
 at 25°C between pH 5.5 and 9.5 Sus scrofa cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide
0.0000004
-
 at 25°C between pH 5.5 and 9.5 Sus scrofa Z-Pro-prolinal
0.00000083
-
 at 25°C between pH 5.5 and 9.5 Sus scrofa benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine