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Literature summary for 3.4.21.26 extracted from

  • Deutch, C.; Krumbholz, R.; Schmid, S.; Bonate, P.; Jurutka, P.
    Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase (2010), Enzyme Microb. Technol., 46, 246-251.
No PubMed abstract available
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
tasidotin
-
 Elizabethkingia meningoseptica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.238
-
 tasidotin
-
 Elizabethkingia meningoseptica
0.25
-
 Z-Gly-Pro-4-nitroanilide
-
 Elizabethkingia meningoseptica

Organism

Organism UniProt Comment Textmining
Elizabethkingia meningoseptica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Elizabethkingia meningoseptica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tasidotin + H2O assay at pH 6.8, 37°C Elizabethkingia meningoseptica tert-butylamine + ?
-
 ?
Z-Gly-Pro-4-nitroanilide + H2O chromogenic assay, assay at pH 7.0, 37°C, reaction stopped by addition of sodium acetate Elizabethkingia meningoseptica Z-Gly-Pro + p-nitroaniline
-
 ?
Z-Gly-Pro-7-amido-4-methylcoumarin fluorogenic assay, assay at pH 6.8, 37°C, reaction stopped by addition of acetic acid Elizabethkingia meningoseptica Z-Gly-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
prolyl oligopeptidase
-
 Elizabethkingia meningoseptica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Elizabethkingia meningoseptica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.311
-
 tasidotin chromogenic assay Elizabethkingia meningoseptica
0.42
-
 tasidotin fluorogenic assay Elizabethkingia meningoseptica