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Literature summary for 3.4.21.26 extracted from

  • Leprince, J.; Cosquer, D.; Bellemere, G.; Chatenet, D.; Tollemer, H.; Jegou, S.; Tonon, M.; Vaudry, H.
    Catabolism of the octadecaneuropeptide ODN by prolyl endopeptidase: identification of an unusual cleavage site (2006), Peptides, 27, 1561-1569.
    View publication on PubMed
Search for more literature for 3.4.21.26

Inhibitors

Inhibitors Comment Organism Structure
S-17092 i.e. (2S,3aS,7aS)-1-[(R,R)-2-phenylcyclopropyl]-2-[(thiazolidin-3-yl)carbonyl]octahydro-1H-indole, specific enzyme inhibitor Flavobacterium sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
urotensin II + H2O Flavobacterium sp. human substrate, cleavage at the canonical post-proline site ?
-
 ?

Organism

Organism UniProt Comment Textmining
Flavobacterium sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O
-
 Flavobacterium sp. benzyloxycarbonyl-Gly-Pro + 4-nitroaniline
-
 ?
peptide QATVGDVNTDRPGLLDLK + H2O i.e. octadecaneuropeptide ODN, the biologically active fragment of diazepam-binding inhibitor, the Ala2 residue is preferred by the enzyme for cleavage, while the Pro-Gly bind is not cleaved, overview Flavobacterium sp. TVGDVNTDRPGLLDLK + GDVNTDRPGLLDLK + QA + QATV
-
 ?
urotensin II + H2O human substrate, cleavage at the canonical post-proline site Flavobacterium sp. ?
-
 ?

Synonyms

Synonyms Comment Organism
prolyl endopeptidase
-
 Flavobacterium sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Flavobacterium sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Flavobacterium sp.