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Literature summary for 3.4.21.26 extracted from

  • Venaelaeinen, J.I.; Garcia-Horsman, J.A.; Forsberg, M.M.; Jalkanen, A.; Wallen, E.A.; Jarho, E.M.; Christiaans, J.A.; Gynther, J.; Maennistoe, P.T.
    Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors (2006), Biochem. Pharmacol., 71, 683-692.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
Sus scrofa
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-pyrrolidine
-
Sus scrofa
4-phenylbutanoyl-L-prolyl-2(S)cyanopyrrolidine
-
Sus scrofa
4-phenylbutanoyl-L-prolyl-pyrrolidine i.e. SUAM-1221 Sus scrofa
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
-
Sus scrofa
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-cyanopyrrolidine amide
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
Sus scrofa ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000022
-
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine pH 7.0, 23°C Sus scrofa
0.000000023
-
4-phenylbutanoyl-L-prolyl-2(S)cyanopyrrolidine pH 7.0, 23°C Sus scrofa
0.000000048
-
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide pH 7.0, 23°C Sus scrofa
0.00000036
-
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-cyanopyrrolidine amide pH 7.0, 23°C Sus scrofa
0.00000039
-
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-pyrrolidine pH 7.0, 23°C Sus scrofa
0.00000097
-
4-phenylbutanoyl-L-prolyl-pyrrolidine pH 7.0, 23°C Sus scrofa