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Literature summary for 3.4.21.26 extracted from

  • Fan, W.; Tezuka, Y.; Kadota, S.
    Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to (2000), Chem. Pharm. Bull., 48, 1055-1061.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(-)-epicatechin IC50: 0.0281 mM, noncompetitive inhibition Elizabethkingia meningoseptica
(-)-epicatechin 3-O-gallate 0.000052 mM, noncompetitive inhibition Elizabethkingia meningoseptica
1,2,6-tri-O-galloylglucose IC50: 0.00044 mM, noncompetitive inhibition Elizabethkingia meningoseptica
3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside IC50: 0.003 mM, noncompetitive inhibition Elizabethkingia meningoseptica
3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside IC50: 0.0149 mM, noncompetitive inhibition Elizabethkingia meningoseptica
3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside IC50: 0.0229 mM, noncompetitive inhibition Elizabethkingia meningoseptica
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside IC50: 0.0105 mM, noncompetitive inhibition Elizabethkingia meningoseptica
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside IC50: 690 nM, noncompetitive inhibition Elizabethkingia meningoseptica
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside IC50: 0.082 mM, noncompetitive inhibition Elizabethkingia meningoseptica
cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside IC50: 0.0028 mM, noncompetitive inhibition Elizabethkingia meningoseptica
gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside IC50: 0.00939 mM, noncompetitive inhibition Elizabethkingia meningoseptica
licuroside IC50: 0.0265 mM, noncompetitive inhibition Elizabethkingia meningoseptica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Elizabethkingia meningoseptica the enzyme plays a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes ?
-
?

Organism

Organism UniProt Comment Textmining
Elizabethkingia meningoseptica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme plays a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes Elizabethkingia meningoseptica ?
-
?

Synonyms

Synonyms Comment Organism
PEP
-
Elizabethkingia meningoseptica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00044
-
IC50: 0.00044 mM, noncompetitive inhibition Elizabethkingia meningoseptica 1,2,6-tri-O-galloylglucose
0.00069
-
IC50: 690 nM, noncompetitive inhibition Elizabethkingia meningoseptica 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside
0.0028
-
IC50: 0.0028 mM, noncompetitive inhibition Elizabethkingia meningoseptica cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside
0.003
-
IC50: 0.003 mM, noncompetitive inhibition Elizabethkingia meningoseptica 3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside
0.00939
-
IC50: 0.00939 mM, noncompetitive inhibition Elizabethkingia meningoseptica gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside
0.0105
-
IC50: 0.0105 mM, noncompetitive inhibition Elizabethkingia meningoseptica 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside
0.0149
-
IC50: 0.0149 mM, noncompetitive inhibition Elizabethkingia meningoseptica 3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside
0.0229
-
IC50: 0.0229 mM, noncompetitive inhibition Elizabethkingia meningoseptica 3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside
0.0265
-
IC50: 0.0265 mM, noncompetitive inhibition Elizabethkingia meningoseptica licuroside
0.0281
-
IC50: 0.0281 mM, noncompetitive inhibition Elizabethkingia meningoseptica (-)-epicatechin
0.082
-
IC50: 0.082 mM, noncompetitive inhibition Elizabethkingia meningoseptica 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside