Literature summary for 3.4.21.22 extracted from

Ahmed, S.S.; Rawala-Sheikh, R.; Monroe, D.M.; Roberts, H.R.; Walsh, P.N.
Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules (1990), J. Biol. Chem., 265, 20907-20911.

Search for more literature for 3.4.21.22

Activating Compound

Activating Compound	Comment	Organism	Structure
Factor VIIIa	-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D47G	factor IXaAL, causes lower rates of factor X activation, Asp47 and the cleavage of Arg145-Ala146 are important structural features required for specific, high affinity factor IXa binding to platelets in the presence of factors VIIIa and factor X	Homo sapiens
R145H	factor IXaCH, causes lower rates of factor X activation, Asp47 and the cleavage of Arg145-Ala146 are important structural features required for specific, high affinity factor IXa binding to platelets in the presence of factors VIIIa and factor X	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00008	-	Factor X	variant protein factor IXaAL	Homo sapiens
0.0001	-	Factor X	-	Homo sapiens
0.00018	-	Factor X	variant protein factor IXaCH	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
factor X + H2O	Homo sapiens	a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
factor X + H2O	a chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa	Homo sapiens	?	-	?
factor X + H2O	-	Homo sapiens	factor Xa	-	?

Synonyms

Synonyms	Comment	Organism
factor IXaAL	variant protein, D47G	Homo sapiens
factor IXaCH	variant protein, R145H	Homo sapiens
factor IXaN	normal protein	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
12.3	-	Factor X	factor IXaAL	Homo sapiens
20.8	-	Factor X	factor IXaCH	Homo sapiens
31.2	-	Factor X	-	Homo sapiens
43.9	-	Factor X	factor IXaAL, platelet-bound	Homo sapiens
44.5	-	Factor X	-	Homo sapiens
110	-	Factor X	factor IXaCH , platelet-bound	Homo sapiens

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Release 2023.1 (January 2023)