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Literature summary for 3.4.21.22 extracted from

  • Neuenschwander, P.F.
    Exosite occupation by heparin enhances the reactivity of blood coagulation factor IXa (2004), Biochemistry, 43, 2978-2986.
    View publication on PubMed
Search for more literature for 3.4.21.22

Activating Compound

Activating Compound Comment Organism Structure
enoxaparin in the presence of bovine pancreatic trypsin inhibitor Homo sapiens
heparin 20fold increased activity, with 30% ethylene glycol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Bovine pancreatic trypsin inhibitor
-
 Homo sapiens
heparin in the presence of 0.3 mM bovine pancreatic trypsin inhibitor Homo sapiens
additional information protamine sulfate is able to reverse the heparin effect of the enhanced inhibition with bovine pancreatic trypsin inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens
-
 factor Xa
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-L-Ala-Gly-Arg-Ser-Leu-amide + H2O
-
 Homo sapiens ?
-
 ?
CH3SO2-D-Leu-Gly-L-Arg-p-nitroanilide + H2O
-
 Homo sapiens CH3SO2-D-Leu-Gly-L-Arg + p-nitroaniline
-
 ?
factor X + H2O
-
 Homo sapiens factor Xa
-
 ?

Synonyms

Synonyms Comment Organism
activated factor IX
-
 Homo sapiens
blood coagulation factor IXa
-
 Homo sapiens
FIXa
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.037
-
 Bovine pancreatic trypsin inhibitor in the presence of heparin Homo sapiens
0.07
-
 Bovine pancreatic trypsin inhibitor in the presence of enoxaparin Homo sapiens
0.7
-
 Bovine pancreatic trypsin inhibitor in the absence of heparin Homo sapiens