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Literature summary for 3.4.21.22 extracted from
- An ordered sequential mechanism for Factor IX and Factor IXa binding to platelet receptors in the assembly of the Factor X-activating complex (2005), Biochem. J., 390, 157-167.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| factor FVIIIa | - |
Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in modified HEK-293 cell line Flp-In-293 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000311 | - |
Factor X | chimera enzyme FIXa7omegaloop7EGF2, in the presence of phospholipid vesicles | Homo sapiens | |
| 0.00000864 | - |
Factor X | chimera enzyme FIX7EGF2, in the presence of phospholipid vesicles | Homo sapiens | |
| 0.0000216 | - |
Factor X | chimera enzyme FIX7EGF2, in the presence of SFLLRN-activated platelets | Homo sapiens | |
| 0.0000259 | - |
Factor X | chimera enzyme FIX7omegaloop, in the presence of SFLLRN-activated platelets | Homo sapiens | |
| 0.0000286 | - |
Factor X | chimera enzyme FIX7omegaloop, in the presence of phospholipid vesicles | Homo sapiens | |
| 0.0000405 | - |
Factor X | chimera enzyme FIXaN, in the presence of SFLLRN-activated platelets | Homo sapiens | |
| 0.0000502 | - |
Factor X | chimera enzyme FIXaN, in the presence of phospholipid vesicles | Homo sapiens | |
| 0.0000508 | - |
Factor X | chimera enzyme FIXa7omegaloop7EGF2, in the presence of SFLLRN-activated platelets | Homo sapiens | |
| 0.3 | - |
Factor X | FIXa, in the absence of platelet surface | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
1 * 28000 + 1 * 18000, SDS-PAGE | Homo sapiens |
| 28000 | - |
1 * 28000 + 1 * 18000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | Homo sapiens | - |
factor Xa | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ion-exchange chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor X + H2O | - |
Homo sapiens | factor Xa | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 28000 + 1 * 18000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FIXa | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
Factor X | FIXa, in the absence of platelet surface | Homo sapiens | |
| 3.2 | - |
Factor X | chimera enzyme FIXaN, in the presence of SFLLRN-activated platelets | Homo sapiens | |
| 3.3 | - |
Factor X | chimera enzyme FIX7EGF2, in the presence of SFLLRN-activated platelets | Homo sapiens | |
| 3.8 | - |
Factor X | chimera enzyme FIX7omegaloop, in the presence of SFLLRN-activated platelets | Homo sapiens |
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