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Literature summary for 3.4.21.21 extracted from
- Current status on tissue factor activation of factor VIIa (2010), Thromb. Res., 125, S11-S12.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| tissue factor | formation of a complex between factor VIIa and tissue factor is necessary to enhance the procoagulant activity of factor VIIa, not only by providing membrane localization, substrate exosites and positioning the active site at an appropriate distance above the surface but also by allosteric enhancement of the enzymatic activity, and this event signals initiation of blood coagulation | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| M306D | the mutant displays barely any tissue factor-induced enhancement in amidolytic activity or active site inhibitor affinity, no increased burial of the protease domain N-terminus and only partial protection of Asn-322 from deglycosylation | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor VIIa | - |
Homo sapiens |
| FVIIa | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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