Literature summary for 3.4.21.21 extracted from

Hathcock, J.J.; Rusinova, E.; Gentry, R.D.; Andree, H.; Nemerson, Y.
Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions (2005), Biochemistry, 44, 8187-8197.

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Activating Compound

Activating Compound	Comment	Organism	Structure
phospholipid vesicle	oleoyl-1,2-diacyl-sn-glycero-3-phosphocholine and dioleoyl-1,2-diacyl-sn-glycero-3-(phospho-L-serine)	Homo sapiens
tissue factor	-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
active-site-inhibited factor Xa	80 nM: 60% inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
factor X + H2O	-	Homo sapiens	factor Xa	-	?

Synonyms

Synonyms	Comment	Organism
TF/VIIa	-	Homo sapiens
tissue factor/factor VIIa	-	Homo sapiens

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Release 2023.1 (January 2023)