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Literature summary for 3.4.21.21 extracted from

  • Sichler, K.; Banner, D.W.; D'Arcy, A.; Hopfner, K.P.; Huber, R.; Bode, W.; Kresse, G.B.; Kopetzki, E.; Brandstetter, H.
    Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions (2002), J. Mol. Biol., 322, 591-603.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of an N-terminally truncated factor VII in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
N-terminally truncated factor VII, activated recombinant factor VII is crystallized in the presence of the reversible S1-site inhibitor benzamidine Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzamidine
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ bound to the backbone-carbonyl groups of Asp72 and Glu75, and to the side-chain carboxylate groups of Glu70 and Glu80 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08709
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant factor VII Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methylsulfonyl-D-Phe-Gly-Arg-4-nitroanilide + H2O
-
Homo sapiens N-methylsulfonyl-D-Phe-Gly-Arg + 4-nitroaniline
-
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