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Literature summary for 3.4.21.21 extracted from

  • Nelsestuen, G.L.; Stone, M.; Martinez, M.B.; Harvey, S.B.; Foster, D.; Kisiel, W.
    Elevated function of blood clotting factor VIIa mutants that have enhanced affinity for membranes: behavior in a diffusion-limited reaction (2001), J. Biol. Chem., 276, 39825-39831.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
P10Q/Q32E mutant enzyme with elevated affinity for membrane. Phospholipid and cell-based assays show that mutant enzyme has an up to 40fold higher function then wild-type enzyme in both tissue-factor dependent reaction and in tissue factor independent reaction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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