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Literature summary for 3.4.21.20 extracted from

  • Zou, F.; Schaefer, N.; Palesch, D.; Bruecken, R.; Beck, A.; Sienczyk, M.; Kalbacher, H.; Sun, Z.; Boehm, B.O.; Burster, T.
    Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients (2011), PLoS ONE, 6, e22815.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.20

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A-penetratin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-L-Val-L-Pro-L-Phe-4-nitroanilide + H2O
-
 Homo sapiens N-succinyl-L-Val-L-Pro-L-Phe + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
CatG
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens both CatG activity and transcript level are elevated in peripheral blood mononuclear cells from type 1 diabetes mellitus patients. Vitamin D reduces CatG activity only in myeloid dendritic cells from healthy donors down

General Information

General Information Comment Organism
malfunction abrogation of CatG activity results in functional inhibition of proinsulin-reactive T cells Homo sapiens
physiological function CatG plays a critical role in proinsulin processing and is important in the activation process of diabetogenic T cells Homo sapiens