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Literature summary for 3.4.21.20 extracted from

  • Wilson, T.J.; Nannuru, K.C.; Singh, R.K.
    Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction (2009), Mol. Cancer Res., 7, 1224-1233.
    View publication on PubMed

Application

Application Comment Organism
medicine cathepsin G as potential therapeutic target Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-tosyl-L-phenylalanine chloromethyl ketone
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
tumor cells implanted on the dorsal skin flap over the calvaria of female mice
-

Source Tissue

Source Tissue Comment Organism Textmining
breast adenocarcinoma cell line C166 tumor cells Mus musculus
-

Synonyms

Synonyms Comment Organism
cathepsin G
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus up-regulated at the tumor-bone interface up

General Information

General Information Comment Organism
malfunction inhibition of cathepsin G reduces active TGF-beta at the tumor-bone interface Mus musculus
physiological function cathepsin G is activating pro-MMP9, involved in enhanced TGF-betra signaling Mus musculus