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Literature summary for 3.4.21.20 extracted from

  • Korkmaz, B.; Moreau, T.; Gauthier, F.
    Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions (2008), Biochimie, 90, 227-242.
    View publication on PubMed
Search for more literature for 3.4.21.20

Application

Application Comment Organism
drug development the enzyme is a therapeutic target Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the gene is located at chromosome 14q11.2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-Aantichymotrypsin
-
 Homo sapiens
alpha1-protease inhibitor
-
 Homo sapiens
alpha2-Macroglobulin
-
 Homo sapiens
chelonianin
-
 Homo sapiens
monocyte neutrophil elastase inhibitor
-
 Homo sapiens
additional information inhibition mechanisms, overview Homo sapiens
protease inhibitor PI6
-
 Homo sapiens
secretory leukocyteprotease inhibitor
-
 Homo sapiens
serpin
-
 Homo sapiens
squamous cell carcinoma antigen 2
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface active enzyme Homo sapiens 9986
-
extracellular active enzyme Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28500
-
 x * 28500 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is one of the major components of the neutrophil primary granules that participate in the non-oxidative pathway of intracellular pathogen destruction, it helps kill bacterial cells and is involved in the degradation of extracellular matrix components during acute and chronic inflammation, the enzyme is important in regulation of immune response, control of cellular signaling through the procession of cytokines and modulation of the cytokine network, biological functions and roles in diseases of cathepsin G, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08311
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the enzyme contains one glycosylation site Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
monocyte enzyme synthesis Homo sapiens
-
neutrophil polymorphonuclear cells, enzyme synthesis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-EPFWEDQ-EDDnp + H2O
-
 Homo sapiens ?
-
 ?
additional information the enzyme is one of the major components of the neutrophil primary granules that participate in the non-oxidative pathway of intracellular pathogen destruction, it helps kill bacterial cells and is involved in the degradation of extracellular matrix components during acute and chronic inflammation, the enzyme is important in regulation of immune response, control of cellular signaling through the procession of cytokines and modulation of the cytokine network, biological functions and roles in diseases of cathepsin G, overview Homo sapiens ?
-
 ?
additional information cathepsin G prefers aromatic or positively charged residues at P1 position, e.g. Phe, Tyr, Lys, or Arg, substrate specificity and active site structure analysis, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 28500 Homo sapiens

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the chymotrypsin family Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens about
-
 12