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Literature summary for 3.4.21.20 extracted from

  • Shimoda, N.; Fukazawa, N.; Nonomura, K.; Fairchild, R.L.
    Cathepsin G is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys (2007), Am. J. Pathol., 170, 930-940.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information acute inflammatory response components are decreased by more than 50% in kidneys from cathepsin G-deficient versus wild-type mice, ischemic kidneys from cathepsin G-deficient mice have a 70% decrease in tubular cell apoptosis with little detectable collagen deposition, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsin G as a critical component sustaining neutrophil-mediated acute tissue pathology and subsequent fibrosis after renal ischemia/reperfusion injury, cathepsin G is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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 129/SvJ wild-type mice
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Source Tissue

Source Tissue Comment Organism Textmining
kidney healthy and ischemic Mus musculus
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neutrophil synthesis and secretion Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin G as a critical component sustaining neutrophil-mediated acute tissue pathology and subsequent fibrosis after renal ischemia/reperfusion injury, cathepsin G is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys, overview Mus musculus ?
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 ?