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Literature summary for 3.4.21.20 extracted from

  • Biggs, J.R.; Yang, J.; Gullberg, U.; Muchardt, C.; Yaniv, M.; Kraft, A.S.
    The human brm protein is cleaved during apoptosis: the role of cathepsin G (2001), Proc. Natl. Acad. Sci. USA, 98, 3814-3819.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone i.e. CK-08, specific for cathepsin G Homo sapiens
L-1-tosylamido-2-phenylethyl chloromethyl ketone weak inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic vesicle
-
Homo sapiens 31410
-
nucleus apoptotic NB4 cells Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human brm protein + H2O Homo sapiens i.e. hbrm, nuclear protein in volved in regulation of chromatin conformation 160 kDa fragment of brm protein + 20 kDa fragment of brm protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-
mast cell
-
Homo sapiens
-
additional information no activity in HeLa cells Homo sapiens
-
NB-4 cell leukemic cell line Homo sapiens
-
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human brm protein + H2O i.e. hbrm, cleavage in vitro after induction of apoptosis, cleavage pattern Homo sapiens 160 kDa fragment of brm protein + 20 kDa fragment of brm protein the 20 kDa fragment contains a bromodomain from the C-terminus of hbrm, the 160 kDa binds less tightly to he nuclear matrix than the full length protein ?
human brm protein + H2O i.e. hbrm, nuclear protein in volved in regulation of chromatin conformation Homo sapiens 160 kDa fragment of brm protein + 20 kDa fragment of brm protein
-
?