Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone | i.e. CK-08, specific for cathepsin G | Homo sapiens | |
L-1-tosylamido-2-phenylethyl chloromethyl ketone | weak inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasmic vesicle | - |
Homo sapiens | 31410 | - |
nucleus | apoptotic NB4 cells | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
human brm protein + H2O | Homo sapiens | i.e. hbrm, nuclear protein in volved in regulation of chromatin conformation | 160 kDa fragment of brm protein + 20 kDa fragment of brm protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |
mast cell | - |
Homo sapiens | - |
additional information | no activity in HeLa cells | Homo sapiens | - |
NB-4 cell | leukemic cell line | Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human brm protein + H2O | i.e. hbrm, cleavage in vitro after induction of apoptosis, cleavage pattern | Homo sapiens | 160 kDa fragment of brm protein + 20 kDa fragment of brm protein | the 20 kDa fragment contains a bromodomain from the C-terminus of hbrm, the 160 kDa binds less tightly to he nuclear matrix than the full length protein | ? | |
human brm protein + H2O | i.e. hbrm, nuclear protein in volved in regulation of chromatin conformation | Homo sapiens | 160 kDa fragment of brm protein + 20 kDa fragment of brm protein | - |
? |