Any feedback?
Literature summary for 3.4.21.20 extracted from
- Heparin-like dextran derivatives as well as glycosaminoglycans inhibit the enzymatic activity of human cathepsin G (2003), FEBS Lett., 537, 23-29.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dermatan sulfate | 25 kDa, protection of laminin and fibronectin against degradation by cathepsin G | Homo sapiens |  |
| heparan sulfate | 60 kDa, protection of laminin and fibronectin against degradation by cathepsin G | Homo sapiens | |
| heparin | 12 kDa, 1:1 binding stoichiometry with cathepsin G, protection of laminin and fibronectin against degradation by cathepsin G | Homo sapiens | |
| additional information | inhibition mechanism and kinetics, effect of ionic strength | Homo sapiens | |
| RG1150 | i.e. carboxymethyl-benzylamide-dextran derivative, protection of laminin and fibronectin against degradation by cathepsin G | Homo sapiens | |
| RG1192 | i.e. carboxymethyl-benzylamide-dextran sulfate derivative, protection of laminin and fibronectin against degradation by cathepsin G | Homo sapiens | |
| RG1503 | i.e. carboxymethyl-dextran sulfate derivative, protection of laminin and fibronectin against degradation by cathepsin G | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Na+ | enhances the ionic interaction and binding affinity and thereby increases the inhibitory effect of glycosaminiglycans and heparin-like dextran derivatives depending on the nature of chemical groups substituted to the dextran | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibronectin + H2O | Homo sapiens | degradation, involved in inflammation process | fragments of fibronectin | - |
ir | |
| laminin + H2O | Homo sapiens | degradation, involved in inflammation process | fragments of laminin | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| monocyte | - |
Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibronectin + H2O | - |
Homo sapiens | fragments of fibronectin | - |
ir | |
| fibronectin + H2O | degradation, involved in inflammation process | Homo sapiens | fragments of fibronectin | - |
ir | |
| laminin + H2O | - |
Homo sapiens | fragments of laminin | - |
? | |
| laminin + H2O | degradation, involved in inflammation process | Homo sapiens | fragments of laminin | - |
ir | |
| succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CatG | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens | |
| 0.00000011 | - |
RG1150 | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester | Homo sapiens | |
| 0.00000017 | - |
RG1192 | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester | Homo sapiens | |
| 0.00000017 | - |
RG1192 | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester, at physiologic ionic strength | Homo sapiens | |
| 0.0000008 | - |
heparin | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide | Homo sapiens | |
| 0.0000008 | - |
dermatan sulfate | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide | Homo sapiens | |
| 0.0000012 | - |
RG1503 | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide, in presence of 0.1 Na+ | Homo sapiens | |
| 0.000003 | - |
heparan sulfate | pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide | Homo sapiens | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | about, very basic protein | - |
12 |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
