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Literature summary for 3.4.21.20 extracted from

  • Robledo, O.; Papaioannou, A.; Ochietti, B.; Beauchemin, C.; Legault, D.; Cantin, A.; King, P.D.; Daniel, C.; Alakhov, V.Y.; Potworowski, E.F.; St-Pierre, Y.
    ICAM-1 isoforms: specific activity and sensitivity to cleavage by leukocyte elastase and cathepsin G (2003), Eur. J. Immunol., 33, 1351-1360.
    View publication on PubMed
Search for more literature for 3.4.21.20

Inhibitors

Inhibitors Comment Organism Structure
alpha1-Aantichymotrypsin acute phase reactant which is up-regulated during inflammation episodes to compensate for the excess of enzymes released from the actvated neutrophils Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
intercellular adhesion molecule-1 + H2O Homo sapiens i.e. ICAM-1, the substrate plays an important role in inflammation and immune response, e.g. to sustain neutrophil infiltration and to confer susceptibility to septic shock, all alternate substrate isoforms but the common form, in model mouse mutants, and in cystic fibrosis patients fragments
-
 ?
additional information Homo sapiens the enzyme probably represents an alternative pathway that modulates the expression of intercellular adhesion molecule-1 on the cell surface ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sputum from humans with cystic fibrosis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
intercellular adhesion molecule-1 + H2O i.e. ICAM-1, a membrane glycoprotein consisting of five extracellular Ig-like domains, a transmembrane domain, and a short cytoplasmic tail, all alternate substrate isoforms or mutant substrate forms but the common form, from mouse and human, substrate specificity is influenced by the ability of the ICAM-1 isoforms to form dimers and larger multimeric complexes Homo sapiens fragments
-
 ?
intercellular adhesion molecule-1 + H2O i.e. ICAM-1, the substrate plays an important role in inflammation and immune response, e.g. to sustain neutrophil infiltration and to confer susceptibility to septic shock, all alternate substrate isoforms but the common form, in model mouse mutants, and in cystic fibrosis patients Homo sapiens fragments
-
 ?
additional information the enzyme probably represents an alternative pathway that modulates the expression of intercellular adhesion molecule-1 on the cell surface Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens