Literature summary for 3.4.21.118 extracted from

Lu, Z.X.; Peng, J.; Su, B.
A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory (2007), Hum. Mutat., 28, 978-984.

Search for more literature for 3.4.21.118

Application

Application	Comment	Organism
additional information	the type II form (longer form) of neuropsin is only expressed in the central nervous system of human. Its origin is less than 5 million years ago. The occurrence of the type II form in human is caused by a human-specific mutation near the novel splicing site. It persists a molecular mechanism for the creation of novel proteins through alternative splicing in the central nervous system during human evolution. Potential importance of the creation of novel splicing forms in the central nervous system in the emergence of human cognition	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	a human-specific T to A mutation triggers the change of splicing pattern. Mutation is not only necessary but also sufficient for type II expression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60259	-	-
Macaca mulatta	Q5V9S7	-	-
Pan troglodytes	Q5V9U8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain	-	Pan troglodytes	-
brain	-	Macaca mulatta	-
central nervous system	-	Homo sapiens	-
placenta	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
neuropsin	-	Homo sapiens
neuropsin	-	Pan troglodytes
neuropsin	-	Macaca mulatta
type I neuropsin	-	Pan troglodytes
type I neuropsin	-	Macaca mulatta
type II neuropsin	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)