Application | Comment | Organism |
---|---|---|
medicine | ectopic expression of KLK7 in pancreatic cancer cells leads to a reduction in cell adhesion to vitronectin that may result from the cleavage of uPAR from the cell surface. KLK 7 expression, plays an important role in the dissemination of tumor cells through the production of soluble uPAR in pancreatic cancer | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | KLK7 is overexpressed in the pancreatic cancer cell line BxPC-3, and in vitro cell adhesion assays are performed to determine alterations in cell adhesion to collagen I, fibronectin, and vitronectin compared with vector-transfected cells. Changes in cell surface expression of alphavbeta3 integrin are examined by flow cytometry, and the release of soluble urokinase-type plasminogen activator receptor (uPAR) is monitored by Western blot analysis. The expression of KLK7 in BxPC-3 cells leads to reduced adhesion to vitronectin but not collagen I or fibronectin. Loss of cell adhesion to vitronectin is not caused by changes in the level of alphavbeta3 integrin cell surface expression. A significant increase in the amount of uPAR shed is observed in KLK7-expressing cells compared with vector-transfected control cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 7 | - |
Homo sapiens |
KLK7 | - |
Homo sapiens |