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Literature summary for 3.4.21.117 extracted from

  • Santin, A.D.; Cane, S.; Bellone, S.; Bignotti, E.; Palmieri, M.; De Las Casas, L.E.; Roman, J.J.; Anfossi, S.; OBrien, T.; Pecorelli, S.
    The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells (2004), Gynecol. Oncol., 94, 283-288.
    View publication on PubMed

Application

Application Comment Organism
medicine because the enzyme appears only in abundance in tumor tissue and contains a secretion signal sequence, suggesting that the enzyme is secreted, it may prove to be a useful diagnostic/prognostic tool for the detection of metastatic or recurrent disease or as a novel molecular target for cervical cancer therapy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
cervical cancer cell line 50% of the primary and 50% of the established cervical cancer cell lines express kallikrein 7 Homo sapiens
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cervical squamous cell carcinoma cell line high expression of the enzyme Homo sapiens
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additional information no expression of kallikrein 7 by normal cervical keratinocytes Homo sapiens
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