Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | estrogen and glucocorticoids cause up-regulation of gene expression | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene KLK7, genetic organization and structure of the kallikrein gene family, clustered on chromosome 19q13.3-q13.4 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | Homo sapiens | involved in pathological keratinization, psoriasis, and ovarian cancer | peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49862 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cleavage of proteins with aromatic side chains in the P1 position | substrate binding pocket contains an Asn residue | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
BT-474 cell | breast carcinoma cell line, enzyme is upregulated by estrogens and slightly by glucocorticoids | Homo sapiens | - |
central nervous system | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
ovarian carcinoma cell | overexpression of the enzyme | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
placenta | low content | Homo sapiens | - |
salivary gland | low content | Homo sapiens | - |
skin | - |
Homo sapiens | - |
testis | low content | Homo sapiens | - |
thymus | low content | Homo sapiens | - |
thyroid gland | low content | Homo sapiens | - |
trachea | low content | Homo sapiens | - |
uterus | low content | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
polypeptide + H2O | - |
Homo sapiens | peptides | - |
? | |
polypeptide + H2O | involved in pathological keratinization, psoriasis, and ovarian cancer | Homo sapiens | peptides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
K7 | - |
Homo sapiens |
SCCE | - |
Homo sapiens |