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Literature summary for 3.4.21.112 extracted from
- Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice (2011), J. Biol. Chem., 286, 29227-29240.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
strain Col2CreERT | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| chondrocyte | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane-bound transcription factor protease, site-1 | - |
Mus musculus |
| S1P | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | postnatal ablation of site-1 protease results in chondrodysplasia and rapid growth plate disruption due to intracellular Col II entrapment concomitant with loss of chondrocyte hypertrophy. S1P ablation at E10.5 results in a complete loss of endochondral bone formation along with the presence of an enhanced cortical bone formation | Mus musculus |
| physiological function | site-1 protease has fundamental roles in the preservation of postnatal growth plate through chondrocyte differentiation and Col II deposition and functions to couple growth plate maturation to trabecular bone development in growing mice | Mus musculus |
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Release 2023.1 (January 2023)
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