Literature summary for 3.4.21.112 extracted from

Zandberg, W.F.; Benjannet, S.; Hamelin, J.; Pinto, B.M.; Seidah, N.G.
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1 (2011), Glycobiology, 21, 1290-1300.

Search for more literature for 3.4.21.112

Cloned(Commentary)

Cloned (Comment)	Organism
expression in CHO K1 and SRD-12B cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(3S,4S,5S,6R)-2-([(2R,3S,4S,5S,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-4-yl]amino)-6-(hydroxymethyl)tetrahydro-2H-thiopyran-3,4,5-triol	i.e. BJ-12-26-1, greatly reduces SKI-1 zymogen processing, and abolishes the processing of substrate SREBP-2	Homo sapiens
(3S,4S,5S,6R)-2-([(2S,3S,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3-yl]amino)-6-(hydroxymethyl)tetrahydro-2H-thiopyran-3,4,5-triol	i.e. BJ-12-21-2, greatly reduces SKI-1 zymogen processing, and abolishes the processing of substrate SREBP-2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sterol regulatory element-binding protein SREBP-2 + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
SKI-1	-	Homo sapiens
subtilisin kexin isoenzyme-1	-	Homo sapiens

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Release 2023.1 (January 2023)