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Literature summary for 3.4.21.112 extracted from

  • Bergeron, E.; Vincent, M.J.; Nichol, S.T.
    Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity (2007), J. Virol., 81, 13271-13276.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.112

Application

Application Comment Organism
medicine SKI-1/S1P processing is strictly required for incorporation of viral glycoproteins. SKI-1/S1P may represent a promising antiviral target Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
SKI-1/S1P deficient SRD12B cells transiently transfected with SKI-1/S1P-containing vector Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information Crimean Congo hemorrhagic fever virus-infected cells deficient in SKI-1/S1P produce no infectious virus, although precursor Gn and precursor Gc accumulate normally in the Golgi apparatus, the site of virus assembly. Complementation of SKI-1/S1P-deficient cells with a SKI-1/S1P expression vector restores release of infectious virus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information SW-13 cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Crimean Congo hemorrhagic fever virus glycoprotein + H2O
-
 Homo sapiens glycoprotein precursor Gn + glycoprotein precursor Gc
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 ?

Synonyms

Synonyms Comment Organism
SKI-1/S1P
-
 Homo sapiens
subtilisin kexin isozyme-1/site-1 protease
-
 Homo sapiens