Application | Comment | Organism |
---|---|---|
medicine | S1P plays an integral role in skeletal development. S1P activity is necessary for a specialized endoplasmic reticulum stress response required by chondrocytes for the genesis of normal cartilage and thus endochondral ossification | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | cartilage-specific S1P knockout mice, exhibit chondrodysplasia and a complete lack of endochondral ossification even though Runx2 expression, Indian hedgehog signaling, and osteoblastogenesis is intact. Substantial increase in chondrocyte apoptosis. Collagen network is disorganized and collagen becomes entrapped in chondrocytes. Endoplasmic reticulum in chondrocytes is engorged and fragmented in a manner characteristic of severe endoplasmic reticulum stress | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | S1P is abundantly expressed in the chondrocytes in the developing wild-type forelimb at all stages | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
S1P | - |
Mus musculus |