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Literature summary for 3.4.21.112 extracted from

  • Sanchez, A.J.; Vincent, M.J.; Erickson, B.R.; Nichol, S.T.
    Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein (2006), J. Virol., 80, 514-525.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.112

Inhibitors

Inhibitors Comment Organism Structure
additional information decanoyl-RVKR-chloromethylketone does not affect SKI-1-mediated processing; decanoyl-RVKR-chloromethylketone inhibition is selective to furin/PCs and does not affect SKI-1-mediated processing Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information SW-13 cell, infected with crimean-Congo hemorrhagic fever virus Homo sapiens
-
additional information SW-13 cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Crimean Congo hemorrhagic fever virus glycoprotein + H2O posttranslational cleavage by furin/PC-mediated processing at its N-terminus at RSKR247 and by SKI-1 at its C-terminus at RRLL519 Homo sapiens ?
-
 ?
glycoprotein precursor Gc + H2O
-
 Homo sapiens ?
-
 ?
glycoprotein precursor Gn + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SKI-1
-
 Homo sapiens