Literature summary for 3.4.21.109 extracted from

Hamilton, B.S.; Gludish, D.W.; Whittaker, G.R.
Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities (2012), J. Virol., 86, 10579-10586.

Search for more literature for 3.4.21.109

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted, e.g. in nasal wash samples	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pro-form influenza hemagglutinin H1 + H2O	Homo sapiens	-	mature influenza hemagglutinin H1 + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y5Y6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
respiratory system	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme shows low rate cleavage of the A/Japan/305/57 (H2) peptide mimic (VPQIESRGL) compared to that for the H1 consensus	Homo sapiens	?	-	?
pro-form influenza hemagglutinin H1 + H2O	-	Homo sapiens	mature influenza hemagglutinin H1 + ?	-	?
pro-form influenza hemagglutinin H1 + H2O	preferred subtype H1N1	Homo sapiens	mature influenza hemagglutinin H1 + ?	-	?
pro-form influenza hemagglutinin H2 + H2O	subtype H2N2	Homo sapiens	mature influenza hemagglutinin H2 + ?	-	?
pro-form influenza hemagglutinin H3 + H2O	subtype H3N2	Homo sapiens	mature influenza hemagglutinin H3 + ?	-	?
VPEKQTRGL + H2O	influenza hemagglutinin H3 cleavage site peptide mimic	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	matriptase performs cleavage activation of the human-adapted influenza virus subtypes exhibiting both subtype and strain specificities	Homo sapiens

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Release 2023.1 (January 2023)