Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA knockdown of the enzyme in MCF-7 cells using three independent non-overlapping synthetic RNA duplexes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | a membrane anchored serine protease | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
x * 70000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-form GPI-anchored serine protease prostasin + H2O | Homo sapiens | activation, prostasin is also a regulator of the epidermal sodium channel like matriptase | mature GPI-anchored serine protease prostasin + ? | - |
? | |
pro-form matriptase + H2O | Homo sapiens | autocatalytic activation | mature matriptase + ? | - |
? | |
prostasin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9Y5Y6 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the enzyme performs autocatalytic activation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | co-expression of matriptase and its substrate serine protease prostasin | Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
breast cancer cell | strong expression association between matriptase and its substrate prostasin in breast cancer | Homo sapiens | - |
BT-20 cell | - |
Homo sapiens | - |
BT-474 cell | - |
Homo sapiens | - |
epithelium | matriptase and prostasin display a near identical spatial expression pattern in the epithelial compartment of breast cancer tissue | Homo sapiens | - |
HCC-1937 cell | - |
Homo sapiens | - |
HCC-1954 cell | - |
Homo sapiens | - |
MCF-10A cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
additional information | not detected in MDA-MB-231, SUM1315, BT-549, and SUM-159 cells | Homo sapiens | - |
additional information | expression of matriptase and prostasin in breast cancer cell lines, overview. No activity in MDA-MB-231 cells, SUM-159 cells, SUM-1315cells, and BT-549 cells | Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |
SUM-102 cell | - |
Homo sapiens | - |
SUM-149 cell | - |
Homo sapiens | - |
SUM-185 cell | - |
Homo sapiens | - |
SUM-190 cell | - |
Homo sapiens | - |
SUM-225 cell | - |
Homo sapiens | - |
SUM-229 cell | - |
Homo sapiens | - |
SUM-44 cell | - |
Homo sapiens | - |
SUM-52 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-form GPI-anchored serine protease prostasin + H2O | activation | Homo sapiens | mature GPI-anchored serine protease prostasin + ? | - |
? | |
pro-form GPI-anchored serine protease prostasin + H2O | activation, prostasin is also a regulator of the epidermal sodium channel like matriptase | Homo sapiens | mature GPI-anchored serine protease prostasin + ? | - |
? | |
pro-form matriptase + H2O | autocatalytic activation | Homo sapiens | mature matriptase + ? | - |
? | |
prostasin + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 70000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
epithin | - |
Homo sapiens |
MT-SP1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the matriptase-prostasin cascade plays a critical role in breast cancer | Homo sapiens |
physiological function | matriptase is a regulator of the epidermal sodium channel | Homo sapiens |