Protein Variants | Comment | Organism |
---|---|---|
additional information | penta-alanine mutants 2-8 and 7-11 show 4 and 4.5fold enhanced proteolytic activity as compared to the wild type enzyme, respectively | Homo sapiens |
S762A | catalytically inactive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | TMPRSS6 is a type II transmembrane serine protease | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hemojuvelin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hemojuvelin + H2O | - |
Homo sapiens | ? | - |
? | |
t-butoxycarbonyl-L-Gln-L-Ala-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | t-butoxycarbonyl-L-Gln-L-Ala-L-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matriptase-2 | - |
Homo sapiens |
TMPRSS6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | TMPRSS6 controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism | Homo sapiens |