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Literature summary for 3.4.21.109 extracted from

  • Beliveau, F.; Brule, C.; Desilets, A.; Zimmerman, B.; Laporte, S.A.; Lavoie, C.L.; Leduc, R.
    Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality (2011), J. Biol. Chem., 286, 29035-29043.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information penta-alanine mutants 2-8 and 7-11 show 4 and 4.5fold enhanced proteolytic activity as compared to the wild type enzyme, respectively Homo sapiens
S762A catalytically inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane TMPRSS6 is a type II transmembrane serine protease Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hemojuvelin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemojuvelin + H2O
-
Homo sapiens ?
-
?
t-butoxycarbonyl-L-Gln-L-Ala-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens t-butoxycarbonyl-L-Gln-L-Ala-L-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
matriptase-2
-
Homo sapiens
TMPRSS6
-
Homo sapiens

General Information

General Information Comment Organism
physiological function TMPRSS6 controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism Homo sapiens