Literature summary for 3.4.21.109 extracted from

Truksa, J.; Gelbart, T.; Peng, H.; Beutler, E.; Beutler, B.; Lee, P.
Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6 (2009), Br. J. Haematol., 147, 571-581.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hemojuvelin + H2O	Mus musculus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hemojuvelin + H2O	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
matriptase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	mice lacking the protease domain of matriptase-2 are crossed with mice lacking hemojuvelin in order to examine the relationship between hemojuvelin and matriptase-2 in vivo. Mice lacking functional matriptase-2 and hemojuvelin exhibit low Hamp (Hepcidin encoding gene) expression, high serum and liver iron, and high transferrin saturation. Double mutant mice also exhibit lower levels of iron in the heart compared to hemojuvelin-deficient mice, demonstrating a possible cardioprotective effect resulting from the loss of matriptase-2	Mus musculus

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Release 2023.1 (January 2023)